Allergen immunotherapy: a new semantic frame work from the EAACI and AAAAI – PRACTALL Consensus Report

Allergen immunotherapy: a new semantic frame work from the EAACI and AAAAI – PRACTALL Consensus Report

Immunotherapy for allergic diseases has entered a new age,marked by the development of a small number of new thera-peutic classes of standardized allergen formulations registeredas pharmaceutical specialties after large, robust, pivotalPhase III clinical trials (1). Furthermore, concepts in generalmedicine and our understanding of the immune system’sfunctions have changed substantially. These developments inpathophysiology, pharmacology, and clinical practice suggestthat there is a need to change and align our current semanticframeworks about the terminology used for immunotherapy.With the aim of promoting the broad uptake of a singlenomenclature, we reviewed current terminologies and sought aconsensus from the European Academy of Allergy and ClinicalImmunology (EAACI) and the American Academy of AllergyAsthma and Immunology (AAAAI) via the PRACTALL ini-tiative (2). We propose the term ‘allergen immunotherapy’ forthe treatment of an allergic disease with an allergen-containingtherapeutic. The rationale for this choice is described below.