Our findings suggest that a natural SARS‐CoV‐2 infection, similar to that observed previously for rhinovirus (RV) infections,9 does not induce a protective antibody response inhibiting the virus‐receptor interaction in all infected patients and therefore underline the urgent need for the development of a SARS‐CoV‐2 vaccine. The molecular interaction assays could be useful for identifying subjects having developed protective antibodies and for screening candidate vaccines to induce antibodies that inhibit the RBD‐ACE2 interaction once they have been validated.