This interesting article shows that the ApoE e4e4 allele increases risks of severe COVID-19 infection, independent of pre-existing dementia, cardiovascular disease, and type-2 diabetes.
Furthermore, as the novel coronavirus SARSCoV-2 causing COVID-19 uses the ACE2 receptor for cell entry. it is notable that ACE2 is highly expressed in type II alveolar cells in the lungs, where ApoE is one of the highly co-expressed genes.

This article was selected by Adam Klocperk, Marketa Bloomfield, Tomáš Milota, and Anna Sediva.