Among severe DHRs, severe cutaneous adverse drug reactions (SCARs), namely Stevens-Johnson syndrome/Toxic epidermal necrolysis (SJS/TEN) syndrome, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome and acute generalized exanthematous pustulosis (AGEP) are the most common ones that are encountered in children, resulting in considerable morbidity and mortality. This will probably remain to be so in the future when one considers the exponentially increasing introduction and consumption of new drugs, especially antibiotics, psychotropic drugs and biologic agents which are highly associated with SCARs or SCAR-like presentations both in adults and children. In spite of their rarity, SCARs are iatrogenic diseases which have a huge impact on pediatric public health due to high mortality rates and morbidity. The prevalence of different entities varies across different age groups, sample populations and geographic locations, as phenotype can be strongly influenced by genetic factors, age-specific factors and prescription patterns of high-risk drugs. The aims of this project related to pediatric SCARs are: 1. First step: To systematically review the limited data about the epidemiology, risk factors, etiology, clinical features, diagnostic methods and management, including acute. 2. As a second step: To develop recommendations for diagnosis and management by a consensus of the TF and to develop clinical guidelines for children.

IG: Drug Allergy

Chair: Semanur Kuyucu

Secretary: Eva Rebelo Gomes