Eosinophilic esophagitis is a Th2 cell-mediated chronic inflammation disorder that can be affected by concomitant IgE-mediated food and respiratory allergies. A causal-effect relation between airborne allergens and EoE is supported by the observation of seasonal deterioration in endoscopic and histologic findings of the esophagus [1] and the beneficial effect of subcutaneous Allergen ImmunoTherapy (AIT) has for a subset of EoE patients [2]. On the other hand, there are reports of EoE development as side-effect of sublingual AIT [3]. AIT with food allergens is aiming to achieve food tolerance in patients with IgE-mediated food allergy. Epicutaneous AIT is one of its proposed modalities and has also been used to treat children with milk-induced EoE [4]. However, a major problem is the development of EoE as a side-effect of oral tolerance induction to foods, hampering protocols’ completion [2].The aim of this EAACI TF is to review the literature on the relation ofEoE and AIT and provide a focused update.References 1. Reed CC, et al. Ann Allergy Asthma Immunol, 2019; 122: 296 2. Cianferoni A, Spergel JM. Immunotherapy 2014; 6: 321.3. Cafone J, et al.Curr Opin Clin Immunol, 2019; 19: 350.4. Spergel JM, et al. Allergy, 2021; 76: 1573.

WG Eosinophilic Esophagitis (IG Food Allergy)

Chair: Constantinos Pitsios 

Secretary: Rossi Carlo Maria