Principles for targeting eicosanoids in the treatment of asthma and allergic diseases

Principles for targeting eicosanoids in the treatment of asthma and allergic diseases

Eicosanoids are a family of fatty acid metabolites that includes prostaglandins, leukotrienes and pro-resolving mediators such as lipoxins and newly-discovered maresins and protectins. Eicosanoids a enzymes involved in their metabolism have been long implicated in the pathogenesis of allergy and asthma but not well understood. Moreove drugs targeting eicosanoids have been widely used for more than a century but our understanding of their activities and response prediction in asthma and allergic diseases is challenged by the comple nature of eicosanoid biology. Hence, in the era of –omics revolution an redefining and uncovering endotypes and theratypes of asthma and allergic diseases, it is important to identify current research needs and opportunities regarding eicosanoid pathway. In this task force, we aim to conduct a comprehensive state of the art review on the role of eicosanoids in the pathogenesis of allergies and asthma and their potential as targets for prevention and therapy of allergic diseases

Basic & Clinical Immunology Section

Chair: Grzegorz Woszczek
Secretary: Milena Sokolowska